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Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer?

机译：雌激素受体-β：为什么会影响雌激素受体-α阳性乳腺癌的临床结局？

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In the previous issue of the journal, Lin and coworkers present data demonstrate that increased expression of estrogen receptor (ER)-β in ER-α-positive breast cancer cells antagonizes a defined group of ER-α/estrogen stimulated genes that are involved in cell cycle regulation and DNA replication. Similar expression patterns for these genes were found human ER-α positive breast tumors expressing higher levels or ER-β, and this correlated with better clinical outcome. The implications for these data, which suggest that ER-β is a positive actor and diagnostic marker for therapeutic outcome, are discussed.

机译：在该期刊的上一期杂志中，Lin及其同事提供的数据表明，ER-α阳性乳腺癌细胞中雌激素受体（ER）-β的表达增加，拮抗了一组与ER-α/雌激素刺激有关的基因细胞周期调节和DNA复制。这些基因的相似表达模式被发现表达较高水平或ER-β的人ER-α阳性乳腺肿瘤，这与更好的临床结果相关。讨论了这些数据的含义，这些结果表明ER-β是治疗结果的阳性因子和诊断标记。

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Shupnik, Margaret A;
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年度 2007
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正文语种 {"code":"en","name":"English","id":9}
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专利

1. Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer? [J] . Margaret A Shupnik Breast Cancer Research . 2007,第3期

机译：雌激素受体-β：为什么会影响雌激素受体-α阳性乳腺癌的临床结局？
2. Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer? [J] . Margaret A Shupnik Breast Cancer Research . 2007,第3期

机译：雌激素受体-β：为什么会影响雌激素受体-α阳性乳腺癌的临床结局？
3. Estrogen receptor-β status influences clinical outcome of triple-negative breast cancer [J] . Goi Sakamoto, Naoko Honma Breast Cancer . 2009,第4期

机译：雌激素受体-β状态影响三阴性乳腺癌的临床结果
4. Study on Molecular Docking of Red Betel (Piper Crocatum Ruiz Pav.) Active Compound and Tamoxifen Drug as an Inhibitor of Estrogen Receptor-α (ER-α) that Plays a Role in Breast Cancer [C] . Siti Imroatul Maslikah, Sri Rahayu Lestari, Nursasi Handayani, International Conference on Life Sciences and Technology . 2020

机译：红色槟榔（吹笛茶叶ruiz＆pav.）活性化合物和三氧化物药物作为发挥乳腺癌作用的雌激素受体-α（ER-α）抑制剂的研究
5. Mechanisms of Action and Efficacy Modulation of Novel Retinoic Acid Metabolism Blocking Agent (RAMBA) VN/12-1 in Estrogen Receptor-α Negative Breast Cancer Model Systems: Targeting Autophagy [D] . Godbole, Abhijit Moreshwar 2011

机译：新型视黄酸代谢阻断剂（RAMBA）VN / 12-1在雌激素受体-α阴性乳腺癌模型系统中的作用和功效调节机制：靶向自噬
6. Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer? [O] . Margaret A Shupnik 2007

机译：雌激素受体-β：为什么会影响雌激素受体-α阳性乳腺癌的临床结局？
7. The Cell Fate Determination Factor DACH1 Is Expressed in Estrogen Receptor-α–Positive Breast Cancer and Represses Estrogen Receptor-α Signaling [O] . Vladimir M. Popov, Jie Zhou, L. Andrew Shirley, 2009

机译：细胞命运测定因子DACH1在雌激素受体-α-阳性乳腺癌中表达并抑制雌激素受体-α信号传导

Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer?

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